Founded in 2006, Olipass is an RNA therapeutics developer built around its proprietary OPNA (peptide nucleic acid-based) platform.
The company describes the technology as capable of efficient cell penetration and gene-expression modulation to suppress disease-causing proteins or restore normal function, positioning it as an answer to the immunogenicity, off-target, and delivery limitations of conventional RNA drugs.
Its flagship candidate is OLP-1002, a non-opioid analgesic designed to selectively inhibit the Nav1.7 pain protein by targeting the SCN9A gene. However, this candidate failed to achieve statistical significance in both Phase 1b and Phase 2a trials, clouding its path to commercialization.
The company's second program is an ALS candidate, 'STMN2-OPNA,' an antisense oligonucleotide developed in collaboration with AskHelpU, an ALS patient-support and research affiliate of China's Chiral Group, aimed at normalizing STMN2 gene expression; it is currently in preclinical testing.
Revenue has come almost entirely from small government research grants and technology fees, repeatedly falling short of the KRW 3 billion annual threshold required to avoid delisting review under the technology-listing special rules.
Amid its management crisis, the company has also pursued business diversification, including mergers with an IT consulting firm and a real estate investment firm and a large apartment-complex asset acquisition, raising questions about the connection to its core drug-development business.
Controlling ownership has changed hands multiple times, from founder Jung Shin to Invest Partners and subsequent third-party share allottees, and a further ownership transfer via investor sale is currently being pursued.
This contrasts with domestic peers in the RNA/oligonucleotide space, such as Olix, which continue to advance global partnering discussions.